R-422B
R-422B is a non-ozone-depleting refrigerant compatible with all standard oils, equipment components, and materials used in R-22 systems.

What is R-422B?
R-422B (a blend of R-125, R-134a, and R-600a) is a hydrofluorocarbon (HFC) refrigerant specifically developed as a drop-in replacement for R-22 in existing medium and low-temperature refrigeration and air conditioning systems. It offers compatibility with traditional mineral oil (MO) and alkylbenzene (AB) lubricants, simplifying the transition process without requiring major system modifications.
R-422B operates at pressures similar to R-22, making it a practical and efficient choice for retrofitting older systems. While its global warming potential (GWP) is higher than newer refrigerants, it provides a reliable and cost-effective solution for systems unable to transition to more advanced alternatives. R-422B is non-toxic and non-flammable, meeting the A1 safety classification, and is widely used in commercial refrigeration, residential AC units, and industrial applications.
Important Note

Key Properties of R-422B
Low Boiling Point
Boils at (1 atm, °F): -42.4, making it efficient for medium and low-temperature refrigeration and air conditioning systems.
Low Pressure Operation
Operates at slightly lower pressures than R-22, requiring similar but retrofitted equipment or none at all.
Similar Energy Efficiency
Offers similar energy efficiency compared to older refrigerants like R-22, but 0 ODP.
Zero Ozone Depletion
Has an Ozone Depletion Potential (ODP) of 0, making it safer for the environment.
Global Warming Potential
Has a GWP of 2525, which is significant but lower than some alternatives.
Non-Flammable
Classified as A1 (lowest toxicity, no flame propagation) by ASHRAE.
Technical Specifications
Applications and Usage
Residential Systems
- Retrofitted residential air conditioning systems originally designed for R-22
- Small-scale cooling units in older applications
Commercial Applications
- Packaged rooftop HVAC units retrofitted from R-22
- Medium-temperature commercial refrigeration systems
- Beverage display coolers and freezers
Industrial Applications
- Cold storage facilities retrofitted from R-22 systems
- Food processing refrigeration units
- Industrial cooling systems requiring R-22 replacements
Specialized Uses
- Medical and laboratory refrigeration units retrofitted from R-22
- Equipment requiring a non-ozone-depleting alternative to R-22
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