R-438A
R-438A is a non-ozone-depleting R-22 replacement and has the closest performance match to R-22 of all no oil change replacement refrigerants.

What is R-438A?
R-438A (a blend of R-32, R-125, R-134a, R-600, and R-601a) is a hydrofluorocarbon (HFC) refrigerant designed as a direct replacement for R-22 in existing air conditioning and refrigeration systems. Its unique formulation makes it compatible with both mineral oil (MO) and alkylbenzene (AB) lubricants, allowing for seamless retrofitting without the need for extensive system modifications.
R-438A operates at pressures and capacities similar to R-22, delivering reliable performance in a wide range of applications. Its versatility makes it suitable for residential, commercial, and industrial systems, including medium and low-temperature refrigeration units. While its global warming potential (GWP) is higher than some next-generation refrigerants, R-438A is an effective and economical solution for systems transitioning away from ozone-depleting substances.
Important Note

Key Properties of R-438A
Low Boiling Point
Boils at (1 atm, °F): -44.2, making it efficient as a direct replacement for R-22 in existing air conditioning and refrigeration systems.
Low Pressure Operation
Operates at slightly lower pressures than R-22, requiring similar but retrofitted equipment or none at all.
Similar Energy Efficiency
Offers similar energy efficiency compared to older refrigerants like R-22, but 0 ODP and less GWP than alternatives.
Zero Ozone Depletion
Has an Ozone Depletion Potential (ODP) of 0, making it safer for the environment.
Global Warming Potential
Has a GWP of 2265, which is significant but lower than some alternatives.
Non-Flammable
Classified as A1 (lowest toxicity, no flame propagation) by ASHRAE.
Technical Specifications
Applications and Usage
Residential Systems
- Limited use in residential settings, primarily for retrofitted air conditioning systems originally designed for R-22
- Small-scale cooling units requiring medium or low-temperature performance
Commercial Applications
- Medium and low-temperature refrigeration systems in supermarkets and convenience stores
- Packaged rooftop HVAC units retrofitted from R-22
- Beverage display coolers, freezers, and ice machines in commercial settings
Industrial Applications
- Large-scale cold storage facilities retrofitted from R-22 systems
- Food processing refrigeration units requiring reliable, medium, and low-temperature cooling
- Industrial cooling systems used in manufacturing and logistics sectors
Specialized Uses
- Medical-grade refrigeration equipment retrofitted from R-22 systems
- Laboratory cooling systems requiring a non-ozone-depleting alternative to R-22
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