R-410A
R-410A is the leading HFC refrigerant replacing R-22 in residential and commercial AC, as well as heat pump, applications.

What is R-410A?
R-410A is a blend of R-32 and R-125 that is 60% higher pressure than R-22 for air conditioning applications and should only be used in new equipment specifically designed to handle the pressure. Systems that are designed for R-410A will have smaller components to perform the same cooling job as R-22. R-410A will require POE lubricants. Retrofitting R-22 equipment is not recommended under any circumstances.
R-410A has replaced R-22 as the preferred refrigerant for use in residential and light commercial air-conditioning and heat pump systems. It has a higher cooling capacity than R-22 and is significantly higher in pressure. R-410A was not designed to retrofit existing R22 systems and should be used only in systems specifically designed for R-410A. It is non toxic and non flammable meeting the highest A1 Classification.
Important Note

Key Properties of R-410A
Low Boiling Point
Boils at (1 atm, °F): -61, making it efficient for heat transfer in AC systems.
High Pressure Operation
Operates at higher pressures than R-22, requiring specially designed equipment.
Improved Energy Efficiency
Offers better energy efficiency compared to older refrigerants like R-22.
Zero Ozone Depletion
Has an Ozone Depletion Potential (ODP) of 0, making it safer for the environment.
Global Warming Potential
Has a GWP of 2088, which is significant but lower than some alternatives.
Non-Flammable
Classified as A1 (lowest toxicity, no flame propagation) by ASHRAE.
Technical Specifications
Applications and Usage
Residential Systems
- Central air conditioning units
- Heat pumps
- Mini-split systems
Commercial Applications
- Rooftop HVAC units
- Chillers for medium-scale cooling systems
- Large-scale air conditioning systems
Light Industrial Applications
- Dehumidification systems
- Air handlers in mixed-use buildings
Specialized Uses
- Portable air conditioners
- Air-to-water heat pump systems
- HVAC systems in recreational vehicles (RVs)
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